Upregulation of Low Density Lipoprotein Receptor by Gemfibrozil, a Hypolipidemic Agent, in Human Hepatoma Cells Through Stabilization of mRNA Transcripts
نویسندگان
چکیده
منابع مشابه
Elevation of low density lipoprotein-receptor mRNA concentration in human hepatoma HepG2 cells by macrolide antibiotics.
Plasma cholesterol which is one of risk factors for the development of coronary heart disease is derived both from dietry fat and de novo synthesis by the liver1}. There are two main therapeutical approaches to lower plasma cholesterol. The first is to stimulate removal of cholesterol by using an ion exchanger like cholestyramine, which absorbs bile acids synthesized from cholesterol and result...
متن کاملFamilial Hypercholesterolemia in Iran: A Novel Frameshift Mutation in Low Density Lipoprotein Receptor (LDLR) Gene
Background and Objective: Familial hypercholesterolemia (FH) is an autosomal trait, which is caused by mutations in Low Density Lipoprotein Receptor (LDLR) gene. FH penetrance is about 100% and worldwide prevalence for heterozygous subjects is almost 1 in 500 and for homozygous 1 in 1,000,000. The patients are at risk of premature coronary heart disease (CHD) due to defective LDLR a...
متن کاملEvalution of In Vitro Effect of Flavonoids on Human Low-Density Lipoprotein Carbamylation
The non-enzymatic carbamylation of low density lipoprotein (LDL) is a naturally occurring chemical modification of apolipoprotein B as a result of condensation between lysine residues and cyanate derived from urea. Carbamylated LDL is poorly recognized by LDL receptors and initiates different processes that can be considered proatherogenic. Thus, LDL carbamylation may contribute to the increase...
متن کاملEvalution of In Vitro Effect of Flavonoids on Human Low-Density Lipoprotein Carbamylation
The non-enzymatic carbamylation of low density lipoprotein (LDL) is a naturally occurring chemical modification of apolipoprotein B as a result of condensation between lysine residues and cyanate derived from urea. Carbamylated LDL is poorly recognized by LDL receptors and initiates different processes that can be considered proatherogenic. Thus, LDL carbamylation may contribute to the increase...
متن کاملA Novel Mutation in Exon 4 of the Low Density Lipoprotein (LDL) Receptor Gene in an Iranian Familial Hypercholesterolemia Patient
Familial hypercholesterolemia (FH) is an autosomal co-dominant disorder of lipid metabolism, caused by mutations in LDL receptor gene. The penetrance of FH is almost 100%, meaning that half of the offspring of affected parents born with disease. The patients are at risk of premature coronary heart disease (CHD). There is no report about the molecular basis of FH in Iran. Identification of mutat...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 1997
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.17.11.2707